Association between history of SARS-CoV-2 infection and severe systemic adverse events after mRNA COVID-19 vaccination among U.S. adults

CONCLUSIONS: History of SARS-CoV-2 infection was significantly associated with severe systemic AEs following dose 1 of mRNA COVID-19 vaccine; the effect varied by vaccine received. Most participants who experienced severe systemic AEs following dose 1 did not require medical attention of any kind for symptoms following dose 2. Vaccine providers can use these findings to counsel patients who had pre-vaccination SARS-CoV-2 infection histories, experienced severe systemic AEs following dose 1, and are considering not receiving additional mRNA COVID-19 vaccine doses.PMID:36372665 | DOI:10.1016/j.vaccine.2022.10.073

Source: Vaccine - November 13, 2022 Category: Allergy & Immunology Authors: Lindsay K Tompkins James Baggs Tanya R Myers Julianne M Gee Paige L Marquez Sharon B Kennedy David Peake Dhruv Dua Anne M Hause Penelope Strid Winston Abara Rebecca Rossetti Tom T Shimabukuro David K Shay Source Type: research