Sequence based HLA-DRB1, -DQB1 and -DPB1 allele and haplotype frequencies in The Gambia

Hum Immunol. 2022 Nov 2:S0198-8859(22)00226-9. doi: 10.1016/j.humimm.2022.10.009. Online ahead of print.ABSTRACTClass II HLA loci DRB1, DQB1 and DPB1 were typed for a total of 939 Gambian participants by locus-specific amplicon sequencing. Participants were from multiple regions of The Gambia and drawn from two studies: a family study aiming to identify associations between host genotype and trachomatous scarring (N = 796) and a cohort study aiming to identify correlates of immunity to trachoma (N = 143). All loci deviated from Hardy-Weinberg equilibrium, likely due to the family-based nature of the study: 608 participants had at least one other family member included in the study population. The most common alleles for HLA-DRB1, DQB1 and DPB1 respectively were DRB1*13:04 (18.8 %), DQB1*03:19 (27.9 %) and DPB1*01:01 (25.4 %). Participants belonged to a variety of ethnicities, including the Mandinka, Fula, Wolof and Jola ethnic groups.PMID:36335053 | DOI:10.1016/j.humimm.2022.10.009
Source: Human Immunology - Category: Allergy & Immunology Authors: Source Type: research