Increasing the delivery of next generation therapeutics from high throughput screening libraries.

Increasing the delivery of next generation therapeutics from high throughput screening libraries. Curr Opin Chem Biol. 2015 Apr 20;26:104-110 Authors: Wigglesworth MJ, Murray DC, Blackett CJ, Kossenjans M, Nissink JW Abstract The pharmaceutical industry has historically relied on high throughput screening as a cornerstone to identify chemical equity for drug discovery projects. However, with pharmaceutical companies moving through a phase of diminished returns and alternative hit identification strategies proving successful, it is more important than ever to understand how this approach can be used more effectively to increase the delivery of next generation therapeutics from high throughput screening libraries. There is a wide literature that describes HTS and fragment based screening approaches which offer clear direction on the process for these two distinct activities. However, few people have considered how best to identify medium to low molecular weight compounds from large diversity screening sets and increase downstream success. PMID: 25909818 [PubMed - as supplied by publisher]
Source: Current Opinion in Chemical Biology - Category: Biochemistry Authors: Tags: Curr Opin Chem Biol Source Type: research