New TREMFYA ® (guselkumab) Data Show an Overall Clinical Response Rate of Approximately 80 Percent in a Phase 2b Induction Study of Adults with Moderately to Severely Active Ulcerative Colitis

SPRING HOUSE, PENNSYLVANIA, October 24, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced new data from the Phase 2b QUASAR Induction Study 1 in adults with moderately to severely active ulcerative colitis (UC) with inadequate responses to previous treatments. The data presented at the 2022 American College of Gastroenterology (ACG) Annual Scientific Meeting show an overall clinical response rate of approximately 80 percent in patients who were randomized to TREMFYA® (guselkumab).Clinical responsea at weeks 12 or 24 of the study was ultimately achieved by 80.2 percent of patients who were randomized to intravenous (IV) TREMFYA 200 mg arm and by 78.5 percent of patients who were randomized to IV TREMFYA 400 mg arm.1 A mean of 52.1 percent of patients randomized to IV TREMFYA who did not achieve clinical response at week 12 and continued treatment with subcutaneous (SC) TREMFYA, achieved clinical response at week 24.1,2 Cumulative efficacy and safety results of the Phase 2b QUASAR Induction Study 1 were among 24 abstracts from Janssen presented at the ACG Annual Scientific Meeting in Charlotte, NC, and virtually from October 21-26. TREMFYA is not approved for the dosages studied or for the treatment of adults with UC in the U.S.3“Despite advances in therapy and numerous treatment options, many patients with moderately to severely active ulcerative colitis still experience inadequate response or intolerance to existing therapies,” said p...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news