Effect of temperature and propylene glycol as a cosolvent on dissolution of clotrimazole

Ann Pharm Fr. 2022 Oct 14:S0003-4509(22)00142-0. doi: 10.1016/j.pharma.2022.10.001. Online ahead of print.ABSTRACTHerein, the solubility study of clotrimazole was performed in a propylene glycol + water system. The solubility values were fitted to various cosolvency equations. The model accuracies were studied with the computation of the mean relative deviations. The thermodynamic behavior was investigated according to the van't Hoff and Gibbs equations for clotrimazole in the propylene glycol + water system. Furthermore, the density data for clotrimazole were determined in mixtures of propylene glycol + water and fitted to the Jouyban-Acree equation.PMID:36252866 | DOI:10.1016/j.pharma.2022.10.001
Source: Annales Pharmaceutiques Francaises - Category: Drugs & Pharmacology Authors: Source Type: research