Review finds little evidence to support gabapentinoid use in bipolar disorder or insomnia

The drugs gabapentin and pregabalin are sometimes prescribed for people with bipolar disorder or insomnia. Research found little evidence that they are effective. The drugs have side effects and can be addictive; the team calls for further trials. Gabapentin and pregabalin (collectively known as gabapentinoids) are licensed in the UK to treat pain and seizures. Pregabalin is also approved for generalised anxiety disorder (when people feel constantly anxious). Both drugs can have side effects, such as drowsiness, dry mouth, dizziness, headache, fatigue and visual disturbance. They can also be addictive. At least half of gabapentinoid prescriptions in the UK are for conditions for which they are not approved. These conditions include insomnia (sleep problems) and bipolar disorder (people have extreme episodes of depression, followed by mania, when they feel high and hyperactive). Researchers gathered existing research on gabapentinoid use in bipolar disorder, anxiety and insomnia. They found that the drugs had a moderate effect for some types of anxiety. But studies did not support the use of the drugs in bipolar disorder or insomnia. The team says these drugs should be used with extreme caution.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news