Differential upregulation of the cannabinoid CB2 receptor in neurotoxic and inflammation-driven rat models of Parkinson's disease.
This study indicates that targeting the CB2 receptor may represent a viable target for anti-inflammatory disease modification in Parkinson's disease. PMID: 25895887 [PubMed - as supplied by publisher]
Publication date: Available online 17 September 2019Source: Neurochemistry InternationalAuthor(s): Meng-Yang Zhu, Muhammad U. Raza, Yanqiang Zhan, Yan FanAbstractAs a classic neurotransmitter in the brain, norepinephrine (NE) also is an important modulator to other neuronal systems. Using primary cultures from rat ventral mesencephalon (VM) and dopaminergic cell line MN9D, the present study examined the neuroprotective effects of NE and its effects on the expression of tyrosine hydroxylase (TH). The results showed that NE protected both VM cultures and MN9D cells against 6-hydroxydopamine-caused apoptosis, with possible in...
Analyst, 2019, Accepted Manuscript DOI: 10.1039/C9AN00751B, PaperArthur Viode, Stephane Epelbaum, Imen Benyounes, Marc Verny, Bruno Dubois, Christophe Junot, francois Fenaille, Foudil Lamari, Francois Becher Tau and α-synuclein are central in several neurodegenerative diseases, including Alzheimer Disease (AD), Dementia with Lewy bodies (DLB) and Parkinson disease (PD). New analytical methods for precise quantification of cerebrospinal... The content of this RSS Feed (c) The Royal Society of Chemistry
Condition: Parkinson Disease Intervention: Device: Deep brain stimulation Sponsor: University of Toronto Recruiting
Conclusion: The use of maltodextrin and xanthan gum showed to be viable in the spray dryer and lyophilization drying processes.
Recent advances in wearable sensor technology and machine learning (ML) have allowed for the seamless and objective study of human motion in clinical applications, including Parkinson's disease, and stroke. Using ML to identify salient patterns in sensor data has the potential for widespread application in neurological disorders, so understanding how to develop this approach for one's area of inquiry is vital. We previously proposed an approach that combined wearable inertial measurement units (IMUs) and ML to classify motions made by stroke patients. However, our approach had computational and practical limitations. We ad...
Conclusions: The findings obtained in this randomized controlled study show the efficacy of mechanical focal vibration, as stimulation of the proprioceptive system, in PD and encourage further investigation. The effect of the device on more severe patients may open a new possibility to identify the most appropriate candidate for the management of gait disturbances and postural instability with FV delivered with Equistasi®.
Genetic variants associated with left-handedness influence brain connectivity and might be related to the pathogenesis of such neuropsychiatric diseases as Parkinson's disease and schizophrenia, researchers from U.K. report.Reuters Health Information
PARKINSON ’S DISEASE is a condition in which parts of the brain become progressively damaged over many years, but currently there’s no cure. Scientists have said a prostate drug could help slow the condition’s progress.
Publication date: Available online 16 September 2019Source: International Review of NeurobiologyAuthor(s): Bin Hu, Taylor ChomiakAbstractPhysical activity and exercise have become a central component of medical management of chronic illness, particular for the elderly who suffer from neurodegenerative disorders that impair their cognition and mobility. This chapter summarizes our recent research showing that a new generation of wearable technology can be adopted as diagnostic and rehabilitation tools for people living with Parkinson's disease. For example, wearable device-enabled 6-min walking test can be automated to elim...
Conclusion: In conclusion, this study is one of the first to address NMS in RLS systematically and the data underlines the need to holistically assess NMS in RLS in order to deliver true value-based healthcare for these patients. PMID: 31522582 [PubMed - as supplied by publisher]