Ischemic conditioning-induced endogenous brain protection: Applications Pre-, Per- or Post-Stroke.

Ischemic conditioning-induced endogenous brain protection: Applications Pre-, Per- or Post-Stroke. Exp Neurol. 2015 Apr 18; Authors: Wang Y, Reis C, Applegate R, Stier G, Martin R, Zhang JH Abstract In the area of brain injury and neurodegenerative diseases, a plethora of experimental and clinical evidence strongly indicates the promise of therapeutically exploiting the endogenous adaptive system at various levels like triggers, mediators and the end-effectors to stimulate and mobilize intrinsic protective capacities against brain injuries. It is believed that ischemic pre- or post-conditioning are actually the strongest known interventions to stimulate the innate neuroprotective mechanism to prevent or reverse neurodegenerative diseases including stoke and traumatic brain injury. Recently, studies showed the effectiveness of ischemic per-conditioning in some organs. Therefore the term ischemic conditioning, including all interventions applied pre-, per- and post- ischemia, which spans therapeutic windows in 3 time periods, has recently been broadly accepted by scientific communities. In addition, it is extensively acknowledged that ischemia-mediated protection not only affects the neurons but also all the components of the neurovascular network (consisting of neurons, glial cells, vascular endothelial cells, pericytes, smooth muscle cells, and venule/veins). The concept of cerebroprotection has been widely used in place of neuroprot...
Source: Experimental Neurology - Category: Neurology Authors: Tags: Exp Neurol Source Type: research