Mesothelioma Patients Live Longer After Aggressive Cancer Surgery

Aggressive pleurectomy/decortication surgery, while often recommended, will cause a significant decrease in pulmonary function with early-stage mesothelioma patients whose symptoms were previously minimal. More symptomatic patients with advanced disease will experience an improved quality of life and a preservation of their current pulmonary status after the same surgery. Those findings were reported in a study from the Department of Surgery, Division of Oncology at the University of Chicago Medical Center, raising questions about aggressive surgery for the early stages of mesothelioma. "Some of the results might be a little unexpected," renowned cardiothoracic surgeon Dr. Wickii Vigneswaran, told asbestos.com. "They gave us something to look closer at. They didn't change our thinking." The study was published last month in the Annals of Thoracic Surgery. Performance Status Is Key The P/D surgery involves the removal of the pleural lining around the lungs, as well as any visible tumors on the lungs or surrounding areas. The surgery also often involves partial or complete resection of the diaphragm, which is rebuilt with prosthetics. The study included 36 mesothelioma patients at the University of Chicago Cancer Center, all of whom had the P/D surgery performed by Vigneswaran, one of the country's leading thoracic surgeons. He also is well known for his expertise in thoracic organ transplants. There were 17 patients with a performance status (PS) of 0 at ...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: Treatment & Doctors Source Type: news

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This study provided proof of concept for the presence of ctDNA in blood of treatment-naive MPM [malignant pleural mesothelioma] patients by the detection of somatic variants that were identified by analysis of a tumor sample,” the authors wrote. “This opens perspective towards its use in MPM.” The post Moving Toward an Earlier Diagnosis of Mesothelioma appeared first on Mesothelioma Center - Vital Services for Cancer Patients &Families.
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
Introduction:  An Old Public Health MenaceThis is somewhat personal.  In the early 1980s, as a general internal medicine fellow, I gave a series of talks about important medical problems that generalist physicians often missed.  One was asbestos related disease.  Although asbestos had been heavily regulated since 1973, there were stilll large numbers of people exposed to it alive in the 1980s.  One of my primitive slides, seemingly a picture of type writing, stated that around then, 2 to 4 million people who had histories of significant asbestos exposure were likely alive.  Asbestos is known t...
Source: Health Care Renewal - Category: Health Management Tags: asbestos cancer conflicts of interest Donald Trump public health Source Type: blogs
Thoracic surgeon Dr. Sunil Singhal at the Abramson Cancer Center has developed glowing tumor technology that should increase the effectiveness of aggressive surgery for malignant pleural mesothelioma. Singhal has shown recently that by adding a contrast agent that makes tumor cells glow, a more complete surgery can be done. This potentially avoids the now almost-inevitable cancer recurrence. “This is a big deal. We could potentially help a lot of patients with this,” Singhal told Asbestos.com. “It could change the entire field [of surgery for mesothelioma].” Singhal and his colleagues from the Abram...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
(CNN) — Parents may want to take a second look at their children’s school supplies this season. The results of lab tests detailed in a report released Tuesday found traces of asbestos, lead and other dangerous chemicals in a number of popular school supplies. The US Public Interest Research Group Education Fund tested dozens of typical classroom materials for toxins. While most were nontoxic, some crayons, markers and binders received a failing grade. Here are some of the products that tested positive for toxic substances: Playskool crayons (36 count) This box set, purchased at Dollar Tree, has traces of asbes...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News Asbestos Local TV Source Type: news
This article represents his opinions. The Environmental Protection Agency would like you to think it is taking an “unprecedented” stand against the hazards of asbestos, the mineral that kills nearly 40,000 Americans each year from mesothelioma, lung cancer and other asbestos-related diseases. It is not. In fact, on June 1, the EPA announced a significant new use rule (SNUR) that will allow companies to manufacture, import and process new asbestos-containing products after it evaluates their potential health dangers. The standards to evaluate those health risks, which are included in a nearly 1,500-page docume...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
A recent test from a consumer advocacy group found toxic levels of asbestos — a mineral that can lead to lung cancer and mesothelioma if inhaled or ingested — in a popular brand of crayons sold by Dollar Tree, Amazon.com and other retailers. The U.S. Public Interest Research Group (U.S. PIRG) Education Fund tested 36 packs of Playskool crayons purchased from a Dollar Tree store in Chicago. All contained dangerous amounts of tremolite asbestos fibers, according to Kara Cook-Schultz, toxics director for U.S. PIRG. The results were part of U.S. PIRG’s “Safer School Supplies: Shopping Guide,” rele...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
Thorac cardiovasc Surg DOI: 10.1055/s-0038-1667008 Background Postpneumonectomy empyema (PPE) is a serious complication even when it is not associated with bronchopleural fistula (BPF). Besides irrigation, an aggressive treatment is usually applied for removing infected material. However, a minimally invasive approach might achieve satisfactory results in selected patients. Methods We retrospectively identified 18 patients presenting with PPE receiving video-thoracoscopic approach. Of these 18 patients, pneumonectomy was performed for nonsmall cell lung cancer in 15 cases, for mesothelioma in 2, and for tra...
Source: The Thoracic and Cardiovascular Surgeon - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Original Thoracic Source Type: research
Abstract BACKGROUND:  Postpneumonectomy empyema (PPE) is a serious complication even when it is not associated with bronchopleural fistula (BPF). Besides irrigation, an aggressive treatment is usually applied for removing infected material. However, a minimally invasive approach might achieve satisfactory results in selected patients. METHODS:  We retrospectively identified 18 patients presenting with PPE receiving video-thoracoscopic approach. Of these 18 patients, pneumonectomy was performed for nonsmall cell lung cancer in 15 cases, for mesothelioma in 2, and for trauma in 1 case. There were 14 m...
Source: The Thoracic and Cardiovascular Surgeon - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Thorac Cardiovasc Surg Source Type: research
This study strengthens the suspicion that, next to germline BAP1 alterations, other genetic factors might predispose families to the development of MM,” the authors wrote. Mutations in only one gene called BAP1 have been shown to increase risk of mesothelioma. However, experts suspect other genes may play a role in the disease. This new study supports the idea that other genes can predispose a person — or even an entire family — to mesothelioma. Hints of Genetic Influence on Mesothelioma Risk Asbestos exposure is the No. 1 cause of mesothelioma. However, some families seem to have more cases of mesothe...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
In conclusion, inhibition of ODC1 by DFMO was crucial in facilitating BCT‑100 treatment in lung adenocarcinoma that was partially mediated by depleting arginine and polyamines with consequent apoptosis. PMID: 30066894 [PubMed - as supplied by publisher]
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
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