Mesothelioma Patients Live Longer After Aggressive Cancer Surgery

Aggressive pleurectomy/decortication surgery, while often recommended, will cause a significant decrease in pulmonary function with early-stage mesothelioma patients whose symptoms were previously minimal. More symptomatic patients with advanced disease will experience an improved quality of life and a preservation of their current pulmonary status after the same surgery. Those findings were reported in a study from the Department of Surgery, Division of Oncology at the University of Chicago Medical Center, raising questions about aggressive surgery for the early stages of mesothelioma. "Some of the results might be a little unexpected," renowned cardiothoracic surgeon Dr. Wickii Vigneswaran, told asbestos.com. "They gave us something to look closer at. They didn't change our thinking." The study was published last month in the Annals of Thoracic Surgery. Performance Status Is Key The P/D surgery involves the removal of the pleural lining around the lungs, as well as any visible tumors on the lungs or surrounding areas. The surgery also often involves partial or complete resection of the diaphragm, which is rebuilt with prosthetics. The study included 36 mesothelioma patients at the University of Chicago Cancer Center, all of whom had the P/D surgery performed by Vigneswaran, one of the country's leading thoracic surgeons. He also is well known for his expertise in thoracic organ transplants. There were 17 patients with a performance status (PS) of 0 at ...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: Treatment & Doctors Source Type: news

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Conditions:   Advanced and/or Metastatic Solid Tumors;   Stage IIIB Not Amenable to Curative Therapy to Stage IV Non-small Cell Lung Cancer;   Advanced/Metastatic Unresectable Malignant Pleural Mesothelioma Interventions:   Drug: INCMGA00012;   Drug: Gemcitabine;   Drug: Cisplatin;   Drug: Pemetrexed;   Drug: Carboplatin;   Drug: Paclitaxel Sponsor:   Incyte Corporation Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 18 April 2019Source: The Annals of Thoracic SurgeryAuthor(s): Fernando Espinoza-Mercado, Jerald D. Borgella, David Berz, Rodrigo F. Alban, Ariella Sarkissian, Taryne A. Imai, Harmik J. SoukiasianAbstractBackgroundCurrent guidelines support cancer-directed surgery, chemotherapy or active surveillance for clinical stages 1 to 3 of epithelial Malignant Pleural Mesothelioma (MPM). Definitive chemotherapy is recommended for sarcomatoid/biphasic histologies. Our objective is to assess compliance with recommendations, measuring their impact on overall survival (OS).MethodsThe National Cancer Dat...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
The Environmental Protection Agency issued a new regulation on Wednesday that will make it tougher to domestically manufacture, import or sell products made with asbestos, the toxic mineral that causes mesothelioma and other diseases. The regulation closes a loophole in the partial ban of asbestos that was legislated almost 30 years ago. It will strengthen the EPA’s ability to review and prohibit the use of a long list of asbestos products that are not banned but have been long abandoned by the industry. The ruling is part of a legislative process that requires the EPA to review its regulation of asbestos under the...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
Conclusions Epidemiological studies have repeatedly helped identify definitive triggers for several diseases. As highlighted in this perspective report, previous studies strongly argue for the interplay between intrinsic factors and putative preventable extrinsic triggers/promoters for CTCL. Given the evidence of geographical regional clustering of CTCL patients, CTCL occurrence in unrelated family members and recent evidence implicating S. aureus in the pathogenesis/progression of CTCL, more research is needed to decipher the precise mechanism by which specific environmental exposures may be driving the pathogenesis of t...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Condition:   Mesothelioma Interventions:   Drug: Nivolumab Injection;   Drug: Ipilimumab Injection Sponsors:   Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins;   Bristol-Myers Squibb Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Advanced Solid Cancer;   Non Small Cell Lung Cancer;   Esophageal Cancer;   Ovarian Cancer;   Malignant Pleural Mesothelioma Intervention:   Drug: APG-2449 Sponsor:   Ascentage Pharma Group Inc. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
The U.S. Environmental Protection Agency has deleted a 45-acre portion of the Libby Asbestos Superfund site from the National Priorities List. The EPA and the Montana Department of Environmental Quality have agreed that institutional controls to prevent any future exposure to asbestos in the area were satisfied. It’s a step closer to finishing the decontamination of the longest-running, man-made environmental disaster in American history. The sprawling Superfund site, which was placed on the National Priorities List in 2002, was originally divided into eight operable units. The units were based upon the extent of co...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
Conclusion The safety profile of BV in patients with solid tumors was similar to the known safety profile of BV. In solid tumors, BV had modest activity as a single agent, which was similar to other second-line treatments already available to patients.
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research
This study was a first of its kind. It involved a head-to-head comparison of acupuncture and cognitive behavioral therapy, enrolled patients with many different types of cancer and included nearly 30% minority participants. Previous studies focused solely on breast cancer and included 90% white participants. Limitations of the previous research make it difficult to determine if the results are applicable to patients with other cancers and people of diverse backgrounds. Cognitive Behavioral Therapy and Acupuncture Are Effective Acupuncture and cognitive behavioral therapy treatments produced clinically meaningful reduction...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
ConclusionsThis analysis provides evidence that the risk of mesothelioma does not decrease after cessation of asbestos exposure, while lung cancer risk does.
Source: International Archives of Occupational and Environmental Health - Category: Occupational Health Source Type: research
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