Tinnitus mapped inside human brain

For the first time, brain signals relating to the constant ringing noise of tinnitus have been mapped across a wide area inside a patient's brain.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news

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Condition:   Tinnitus, Subjective Interventions:   Drug: Wuling Capsule;   Drug: Oryzanol Sponsor:   Xijing Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 18 September 2018Source: NeuroscienceAuthor(s): Amarins N. Heeringa, Calvin Wu, Christopher Chung, Michael West, David Martel, Leslie Liberman, M. Charles Liberman, Susan E. ShoreAbstractTinnitus alters auditory-somatosensory plasticity in the cochlear nucleus (CN). Correspondingly, bimodal auditory-somatosensory stimulation treatment attenuates tinnitus, both in animals and humans (Marks et al., 2018). Therefore, we hypothesized that tinnitus is associated with altered somatosensory innervation of the CN. Here, we studied the expression of vesicular glutamate transporters 1 and 2 (VGLUT1...
Source: Neuroscience - Category: Neuroscience Source Type: research
Objective: We investigated the hypothesis that childhood obesity is a risk factor for sensorineural hearing loss (SNHL) independent of other metabolic risk factors. Study Design: A complex, multistage, stratified geographic area design for collecting representative data from noninstitutionalized US population. Methods: A total of 5,638 adolescents between age 12 and 19 from the NHANES database (2005–2010) were studied. Subjects with body mass index>= 95th percentile were classified as obese. SNHL was defined as average pure-tone greater than 15 dB HL for 0.5, 1, and 2 kHz or 3, 4, 6, and 8 kHz in at ...
Source: Otology and Neurotology - Category: ENT & OMF Tags: Sensorineural Hearing Loss and Tinnitus Source Type: research
Objective: Evaluate the relationship between objective audiometric and vestibular tests and patient symptoms in superior canal dehiscence (SCD) syndrome. Study Design: Retrospective chart review. Setting: Tertiary care center. Patients: Ninety-eight patients with SCD, preoperative threshold audiograms, cervical vestibular evoked myogenic potential (cVEMP) thresholds, and computed tomography (CT) imaging were included. Clinical reports were reviewed for self-reported SCD symptoms. Twenty-five patients completed the Hearing Handicap Inventory (HHI), Dizziness Handicap Inventory (DHI), Autophony Index (AI), and the...
Source: Otology and Neurotology - Category: ENT & OMF Tags: Vestibular Disorders Source Type: research
ConclusionComprehensive neurotological workup results in diagnoses that would go unrecognized otherwise, allowing patients to receive prompt treatment for medically important conditions, some of which may be causally related to their neurotologic complaints. However, the value of each study for routine testing of patients with neurotologic complaints remains controversial; and the evidence presented herein should help practitioners determine what studies should be included in his/her patient assessment.
Source: American Journal of Otolaryngology - Category: Endocrinology Source Type: research
Authors: Ralli M, D'Aguanno V, Di Stadio A, De Virgilio A, Croce A, Longo L, Greco A, de Vincentiis M Abstract Immune-mediated inner ear disease can be primary, when the autoimmune response is against the inner ear, or secondary. The latter is characterized by the involvement of the ear in the presence of systemic autoimmune conditions. Sensorineural hearing loss is the most common audiovestibular symptom associated with systemic autoimmune diseases, although conductive hearing impairment may also be present. Hearing loss may present in a sudden, slowly, rapidly progressive or fluctuating form, and is mostly bilate...
Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
EXCLUSIVE British audiologists have come up with a range of niggling noises, from screeching and roaring tones to the buzz of electrical sparks, to raise awareness of tinnitus.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Publication date: Available online 13 September 2018Source: American Journal of OtolaryngologyAuthor(s): Stephanie Y. Chen, Gregory J. Zipfel, Cameron C. Wick
Source: American Journal of Otolaryngology - Category: Endocrinology Source Type: research
Publication date: Available online 12 September 2018Source: NeuroscienceAuthor(s): David T. Martel, Thibaut R. Pardo-Garcia, Susan E. ShoreAbstractFollowing noise overexposure and tinnitus-induction, fusiform cells of the dorsal cochlear nucleus (DCN) show increased spontaneous firing rates (SFR), increased spontaneous synchrony and altered stimulus-timing dependent plasticity (StDP), which correlate with behavioral measures of tinnitus. Sodium salicylate, the active ingredient in aspirin, which is commonly used to induce tinnitus, increases SFR and activates NMDA receptors in the ascending auditory pathway. NMDA receptor ...
Source: Neuroscience - Category: Neuroscience Source Type: research
(Karolinska Institutet) Researchers at Karolinska Institutet in Sweden have identified four types of neurons in the peripheral auditory system, three of which are new to science. The analysis of these cells can lead to new therapies for various kinds of hearing disorders, such as tinnitus and age-related hearing loss. The study is published in Nature Communications.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
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