The influence of carob powder on lipid profile and histopathology of some organs in rats

Abstract The present study aimed to investigate the effect of two levels of carob powder 10 and 20 % on lipid profile. Forty male Sprague–Dawley rats were divided into two groups. The first group was fed on a basal diet and acts as a control group. The second group was fed on a hyperlipidemic diet (a basal diet plus 10 % animal fat and 1 % cholesterol). After 6 weeks, the second group was divided into three even subgroups: subgroup 1 was fed on a hyperlipidemic diet, subgroup 2 was fed on a hyperlipidemic diet plus 10 % carob powder, and subgroup 3 was fed on a hyperlipidemic diet plus 20 % carob powder. At the end of the experimental period, serum samples were collected to measure total cholesterol (TC), triglyceride (TG), high-density lipoproteins (HDL), low-density lipoproteins (LDL), and very-low-density lipoproteins (VLDL). Heart and kidney samples were taken for histopathological examination. The obtained results revealed that feeding rats with 10 and 20 % carob powder improved lipid profile parameters and histopathological characteristics in the heart and kidney of experimental rats.
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research

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Source: American Heart Journal - Category: Cardiology Source Type: research
Protective effect of rivaroxaban on arteriosclerosis obliterans in rats through modulation of the toll-like receptor 4/NF-κB signaling pathway. Exp Ther Med. 2019 Sep;18(3):1619-1626 Authors: Lou X, Yu Z, Yang X, Chen J Abstract The aim of the present study was to explore the pharmacological role of rivaroxaban in rats with arteriosclerosis obliterans (ASO) and the potential mechanism of its action. A total of 60 adult male Sprague Dawley (weighing 210-250 g) were randomly assigned into either the sham group, model group or Riv group. Rats in the sham group were fed a normal diet, whereas those i...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Authors: Hou C, Zheng B, Wang XG, Zhang B, Shi QP, Chen M Abstract Previous studies have reported that short-term statin loading effectively protects statin-naive patients with mild renal insufficiency from contrast-induced acute kidney injury (CI-AKI). The aim of the present study was to determine whether patients with more advanced chronic kidney disease (CKD) and long-term statin therapy also benefit from high-loading statin pretreatment. A total of 256 consecutive patients with moderate-to-severe CKD receiving long-term statin therapy and undergoing percutaneous coronary intervention (PCI) or coronary artery an...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
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Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: health and fitness Causes of Testicular Pain in Children Kidshealth Testicle Pain Testicle Pain in Children Testicular Pain in Kids Source Type: blogs
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Source: Tropical Animal Health and Production - Category: Veterinary Research Source Type: research
AbstractHereditary spastic paraparesis (HSP) is a progressive neurodegenerative disorder, characterized by progressive lower limb weakness and spasticity. Multiple genes are associated with both the pure and complicated HSP types. Our study is aimed at seeking for novel genetic basis of HSP in a family with two affected siblings. Genetic analysis using whole exome sequencing was conducted in a family quartet with two female siblings, who presented with complicated HSP featuring slowly progressive paraparesis, mild-moderate intellectual disability, normal head circumference (HC), and normal magnetic resonance imaging (MRI)....
Source: Neurogenetics - Category: Genetics & Stem Cells Source Type: research
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Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
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Source: Jornal Vascular Brasileiro - Category: Surgery Source Type: research
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Source: Daily Express - Health - Category: Consumer Health News Source Type: news
We report a case of statin induced necrotizing autoimmune myopathy (SINAM), a rare variant of statin-induced myopathy.A 64-year-old gentleman on atorvastatin presented with muscle weakness, initial laboratory results showed elevated liver function tests, a creatine phosphokinase (CPK) of 8200 IU/L and positive urine myoglobin. Despite discontinuing atorvastatin, his CPK remained persistently elevated. Muscle biopsy was consistent with necrotizing myopathy. Anti - HMG CoA reductase antibody was strongly positive. Steroids followed by intravenous immunoglobulin were given. His muscle weakness, CPK, and liver functions gradua...
Source: Journal of the Saudi Heart Association - Category: Cardiology Source Type: research
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