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Single vs Bilateral Lung Transplant in IPF and COPDSingle vs Bilateral Lung Transplant in IPF and COPD

A new analysis looks at the benefits of using a single- vs double-lung transplant in patients with IPF or COPD. Medscape Pulmonary Medicine
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Pulmonary Medicine Commentary Source Type: news

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Purpose of review Lung transplantation is a life-saving treatment for several end stage lung diseases. Over the last two decades, the number of lung transplantation performed worldwide has steadily increased but several thousand people still die every year waiting for lung transplantation. However, the optimal procedure for lung transplantation in non-septic lung conditions remains debatable. Recent findings In pulmonary fibrosis and COPD, many recent studies suggest superiority of bilateral lung transplantation over single lung transplantation when long-term survival is evaluated; consequently, bilateral lung transpl...
Source: Current Opinion in Organ Transplantation - Category: Surgery Tags: THORACIC TRANSPLANTATION: Edited by Abbas Ardehali Source Type: research
Publication date: Available online 5 May 2018 Source:The Annals of Thoracic Surgery Author(s): Branden W. Luna, Luca Paoletti, Chadrick E. Denlinger, Nicholas J. Pastis, Timothy P. Whelan Airway complications following lung transplantation are well described and can lead to significant morbidity and mortality. Treatment options for anastomotic dehiscence include expectant management, placement of endobronchial stents, or surgical repair. The use of fibrin sealant instilled via bronchoscopy to seal a dehiscence has not been well described. Our patient is a 57 year old male who underwent orthotropic bilateral lung transplan...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Abstract Airway complications following lung transplantation are well described and can lead to significant morbidity and mortality. Treatment options for anastomotic dehiscence include expectant management, placement of endobronchial stents, or surgical repair. The use of fibrin sealant instilled via bronchoscopy to seal a dehiscence has not been well described. Our patient is a 57 year old male who underwent orthotropic bilateral lung transplantation for end stage COPD. He was found to have a partial bronchial anastomosis dehiscence and subsequently treated with endobronchial fibrin sealant glue instillation. Th...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Ann Thorac Surg Source Type: research
Conditions:   Idiopathic Pulmonary Fibrosis;   Emphysema or COPD Interventions:   Biological: CD3/CD19 negative hematopoietic stem cells;   Drug: Rituximab;   Drug: Alemtuzumab;   Drug: Fludarabine;   Drug: Thiotepa;   Drug: G-CSF;   Drug: Hydroxyurea Sponsor:   Paul Szabolcs Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Abstract The repurposing of drug delivery by the pulmonary route has been applied to treatment and prophylaxis of an increasingly wide range of respiratory diseases. Repurposing has been most successful for the delivery of inhaled bronchodilators and corticosteroids in patients with asthma and chronic obstructive pulmonary disease (COPD). Repurposing utilizes the advantages that the pulmonary route offers in terms of more targeted delivery to the site of action, the use of smaller doses, and a lower incidence of side-effects. Success has been more variable for other drugs and treatment indications. Pulmonary deliv...
Source: Advanced Drug Delivery Reviews - Category: Drugs & Pharmacology Authors: Tags: Adv Drug Deliv Rev Source Type: research
Abstract PURPOSE OF REVIEW: Lung transplantation is a life-saving treatment for several end stage lung diseases. Over the last two decades, the number of lung transplantation performed worldwide has steadily increased but several thousand people still die every year waiting for lung transplantation. However, the optimal procedure for lung transplantation in non-septic lung conditions remains debatable. RECENT FINDINGS: In pulmonary fibrosis and COPD, many recent studies suggest superiority of bilateral lung transplantation over single lung transplantation when long-term survival is evaluated; consequently, bi...
Source: Current Opinion in Organ Transplantation - Category: Transplant Surgery Authors: Tags: Curr Opin Organ Transplant Source Type: research
Authors: Janssen R, Piscaer I, Wouters EF Abstract INTRODUCTION: Current pharmacologic therapy of chronic obstructive pulmonary disease (COPD) can reduce respiratory symptoms and exacerbation frequency. However, no single COPD intervention except for lung transplantation has proven effective in recovering lung function. Lung elasticity is reduced in COPD lungs, which is for a large part due to chronically enhanced elastin degradation. Elastin calcification and formation of advanced glycation end products (AGEs) may also contribute to this. Areas covered: We propose inhalation therapy to induce repair of damaged pul...
Source: Expert Review of Respiratory Medicine - Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research
Increasing evidence indicates a role for recipient autoimmunity in the pathogenesis of graft rejection. COPD, which accounts for over 25% of all lung transplants (LTx), is caused by chronic inflammation, which has been shown to lead to an autoimmune phenotype characterized by the production of extracellular matrix (ECM) autoreactive antibodies (aAbs). Here we investigated the impact of recipient pre-existing aAbs on early post-transplant (Tx) outcomes. We hypothesize that ischemia reperfusion injury (IRI) liberates ECM epitopes and facilitate aAb binding, leading to lung injury.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
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