Pathogenesis and Immunobiology of Brucellosis: Review of Brucella-Host Interactions.

Pathogenesis and Immunobiology of Brucellosis: Review of Brucella-Host Interactions. Am J Pathol. 2015 Apr 16; Authors: de Figueiredo P, Ficht TA, Rice-Ficht A, Rossetti CA, Adams LG Abstract This review of Brucella-host interactions and immunobiology discusses recent discoveries as the basis for pathogenesis-informed rationales to prevent or treat brucellosis. Brucella spp., as animal pathogens, cause human brucellosis, a zoonosis that results in worldwide economic losses, human morbidity, and poverty. Although Brucella spp. infect humans as an incidental host, 500,000 new human infections occur annually, and no patient-friendly treatments or approved human vaccines are reported. Brucellae display strong tissue tropism for lymphoreticular and reproductive systems with an intracellular lifestyle that limits exposure to innate and adaptive immune responses, sequesters the organism from the effects of antibiotics, and drives clinical disease manifestations and pathology. Stealthy brucellae exploit strategies to establish infection, including i) evasion of intracellular destruction by restricting fusion of type IV secretion system-dependent Brucella-containing vacuoles with lysosomal compartments, ii) inhibition of apoptosis of infected mononuclear cells, and iii) prevention of dendritic cell maturation, antigen presentation, and activation of naive T cells, pathogenesis lessons that may be informative for other intracellular pathogens....
Source: The American Journal of Pathology - Category: Pathology Authors: Tags: Am J Pathol Source Type: research