Thromboelastography and thrombin generation assessments for pediatric severe hemophilia A patients are highly variable and not predictive of clinical phenotypes

CONCLUSIONS: In vitro hemostatic assay results of samples containing platelets showed concordance. Assay results were not predictive of FVIII requirements or correlated with other clinical parameters. SHA patient heterogeneity is influenced by factors other than baseline hemostatic activity.PMID:36186102 | PMC:PMC9511091 | DOI:10.1002/rth2.12800

Source: Thrombosis and Haemostasis - October 3, 2022 Category: Hematology Authors: Natalie Mathews Fred G Pluthero Margaret L Rand Ann Marie Stain Manuel Carcao Victor S Blanchette Walter H A Kahr Source Type: research