DNA directed immobilization glycocluster array: applications and perspectives.

DNA directed immobilization glycocluster array: applications and perspectives.
Curr Opin Chem Biol. 2014 Jan 15;18C:46-54
Authors: Chevolot Y, Laurenceau E, Phaner-Goutorbe M, Monnier V, Souteyrand E, Meyer A, Géhin T, Vasseur JJ, Morvan F
Abstract
The present review concerns the recent advances in DNA directed immobilization (DDI) based glycocluster array. The impact of glycan immobilization on subsequent interactions with protein is discussed and the consequent pros and cons of DDI-based glycocluster array are reviewed. Finally, application in the discovery of anti-pathogen molecules is illustrated by screening for galactose or fucose glycoclusters targeting two Pseudomonas aeruginosa virulence factors (PA-IL and PA-IIL).
PMID: 24440778 [PubMed - as supplied by publisher]

Source: Current Opinion in Chemical Biology - January 15, 2014 Category: Biochemistry Authors: Chevolot Y, Laurenceau E, Phaner-Goutorbe M, Monnier V, Souteyrand E, Meyer A, Géhin T, Vasseur JJ, Morvan F Tags: Curr Opin Chem Biol Source Type: research