Interleukin-34 {-} a new modulator of human and experimental inflammatory bowel disease

Inflammatory bowel diseases (IBD), where Crohn’s disease (CD) and ulcerative colitis (UC) represent the two main forms, are chronic inflammatory conditions of the intestine. Macrophages play a central role for IBD pathogenesis and are regulated by major differentiation factors such as colony-stimulating factor 1 (CSF-1) in homeostasis and inflammation. Interleukin (IL)-34 has recently been discovered as a second ligand for the CSF-1 receptor (CSF-1R). However, expression and involvement of IL-34 in IBD remain unknown. Here, we investigated the expression of IL34, CSF1, and their shared receptor CSF1R in normal human ileum and colon, in inflamed and non-inflamed tissues of CD and UC patients, and in a mouse model of experimental colitis. We found distinct expression patterns of IL34 and CSF1 in ileum and colon, with higher IL34 in ileum and, on the contrary, higher CSF1 in colon. Further, IL34 and CSF1 expression was increased with inflammation in IBD patients and in experimental colitis. In humans, infiltrating cells of the lamina propria and intestinal epithelial cells expressed IL-34, and TNF-α regulated IL-34 expression in intestinal epithelial cells through the NF-κΒ pathway. These data demonstrate the expression pattern of IL-34 in ileum and colon and suggest IL-34 as a new modulator of inflammation in IBD.
Source: Clinical Science - Category: Biomedical Science Authors: Source Type: research

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Authors: Mahamid M, Bar-Gil Shitrit A, Amara H, Koslowsky B, Ghantous R, Safadi R Abstract BACKGROUND: Crohn's disease and ulcerative colitis are the two major classic presentations of inflammatory bowel diseases (IBD). Studies have shown a wide variation in the incidence and prevalence attributed to different geographic and ethnic populations. OBJECTIVES: To assess the clinical characteristics of IBD among Arabs in Israel and to compare them to characteristics of IBD among Ashkenazi Jews. METHODS: This retrospective, comparative study compared the clinical characteristics of IBD among 150 Arabs from the Ho...
Source: The Israel Medical Association Journal - Category: General Medicine Tags: Isr Med Assoc J Source Type: research
Elective abdominal surgery for inflammatory bowel disease is common. Surgery for Crohn ’s disease is not curative, and treatment must be individualized to the disease process. Surgery for ulcerative colitis generally is curative but consideration of patient-specific factors is important for staging of the procedure and determining whether ileal pouch–anal anastomosis is appropriat e.
Source: Surgical Clinics of North America - Category: Surgery Authors: Source Type: research
CONCLUSION: In this study, we demonstrate that risk factors for NAFLD and LF in the IBD population do not differ from those in the general population. PMID: 31602167 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - Category: Gastroenterology Authors: Tags: World J Gastroenterol Source Type: research
ConclusionCombination therapy with 50  mg allopurinol led to a decrease of 6-TGN levels compared with 100 mg allopurinol. Disease activity, side effects, and patient experience, however, were similar between allopurinol 100 and 50 mg. UC patients seem to benefit and prefer lower doses whereas the contrary is seen in CD patients.Trial registrationEudraCT trial registry - number2016-001638-84
Source: European Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Source Type: research
Conclusions: We demonstrate that the risk of relapse in ulcerative colitis can be predicted by consecutively measuring faecal EDN every third month, and suggest EDN as a complementary faecal marker to calprotectin to predict future relapse in ulcerative colitis. Our finding of higher EDN in Crohn's disease-patients staying in remission than in those who relapsed indicates different functions of the protein in ulcerative colitis and Crohn's disease. PMID: 31577465 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
Conclusions: Defining the landscape of MNPs in MLNs provided evidence for expansion of CD163+ Mono/MΦ-like cells in UC only, highlighting a distinction between UC and CD, and thus the potential co ntribution of monocyte-like cells in driving colitis.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Although the number of available therapies for the treatment of ulcerative colitis (UC) and Crohn ’s disease (CD) continues to expand, a significant portion of patients with inflammatory bowel disease (IBD) will require surgical intervention. Surgery remains an integral part of the treatment algorithm for patients with UC and CD, and thus multidisciplinary approaches to the perioperative and p ostoperative management of patients with IBD are critical to improving outcomes during these periods. New mechanisms of biologic therapies are emerging and new treatment strategies focused on earlier and potentially more aggres...
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Source Type: research
Condition:   Ulcerative Colitis Intervention:   Drug: Tauroursoursodeoxycholic acid, brand name Tudcabil Sponsors:   Washington University School of Medicine;   Crohn's and Colitis Foundation Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
More News: Biomedical Science | Crohn's Disease | Dermatology | Inflammatory Bowel Disease | Science | Ulcerative Colitis