Bergenin ameliorates cognitive deficits and neuropathological alterations in sodium azide-induced experimental dementia

Conclusions: The findings of our study exhibit that the cognitive restoration potential of bergenin may be attributed to its modulatory effects against cholinesterase, oxidative stress, and inflammatory markers, as well as its neuroprotective actions, thus aligning it as a possible therapy for Alzheimer’s disease-related dementia. The study also fortifies the significance of PPAR-γ receptors in dementia.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research