Subcortical structures associated with childhood trauma and perceived stress in schizophrenia

CONCLUSIONS: Patients with schizophrenia had more exposure to early-life trauma and poorer stress coping. Both childhood trauma and perceived stress were associated with smaller amygdala volumes. The relationship between early-life trauma and perceived stress was mediated by right amygdala GMV in patients with schizophrenia. These findings together suggest the long-term effects of childhood trauma on perceived stress and the subcortical volumetric correlates of the effects in schizophrenia.PMID:36154670 | DOI:10.1017/S0033291722002860

Source: Psychological Medicine - September 26, 2022 Category: Psychiatry Authors: Fengmei Fan Shuping Tan Shibo Liu Song Chen Junchao Huang Zhiren Wang Fude Yang Chiang-Shan R Li Yunlong Tan Source Type: research