Dynamic Alteration in HLA-E Expression and Soluble HLA-E via Interaction with Natural Killer Cells in Gastric Cancer

CONCLUSIONS: HLA-E expression dynamically changes on GC cells and in conditioned medium. Furthermore, soluble HLA-E can contribute to immune escape in GC cell lines, which may have significance in clinical practice. Moreover, soluble HLA-E may be a potential prognostic biomarker.PMID:36149610 | DOI:10.1245/s10434-022-12505-0

Source: Ann Oncol - September 23, 2022 Category: Cancer & Oncology Authors: Takeshi Morinaga Masaaki Iwatsuki Kohei Yamashita Noriko Yasuda-Yoshihara Taishi Yamane Chihiro Matsumoto Kazuto Harada Kojiro Eto Junji Kurashige Takatsugu Ishimoto Yoshifumi Baba Yuji Miyamoto Naoya Yoshida Hideo Baba Source Type: research