Development of a potent melanoma vaccine capable of stimulating CD8 + T-cells independently of dendritic cells in a mouse model

This study shows that the B16-F10-4-1BBL-B7.1-IFNγ/β anticancer vaccine acted as a highly effective antigen-presenting cell and is likely to be able to directly stimulate CD8+ T-cells, without requiring co-stimulatory signals from either CD4+ T-cells or DCs, and warrants translation of this technology into the clinical setting.
Source: Cancer Immunology, Immunotherapy - Category: Cancer & Oncology Source Type: research