Genetics of Pancreatic Neuroendocrine Tumors
Pancreatic neuroendocrine tumors (pNETs) represent a relatively rare disease; however, the incidence has been increasing during the last 2 decades. Next generation sequencing has greatly increased our understanding of driver mutations in pNETs. Sporadic pNETs have consistently presented with mutations in MEN1, DAXX/ATRX, and genes related to the mammalian target of rapamycin pathway. Inherited pNETs have traditionally been associated with multiple endocrine neoplasia type 1, von Hippel-Lindau syndrome, neurofibromatosis type 1, and tuberous sclerosis complex. The current review expands on the existing knowledge and the relevant updates on the genetics of pNETs.
Source: Hematology/Oncology Clinics of North America - Category: Cancer & Oncology Authors: Chirayu Mohindroo, Florencia McAllister, Ana De Jesus-Acosta Source Type: research
More News: Brain | Cancer & Oncology | Genetics | Hematology | Men | Multiple Endocrine Neoplasia | Multiple Endocrine Neoplasia Syndrome | Neurofibromatosis | Neurology | Pancreas | Rare Diseases | Tuberous Sclerosis