Cervical cancer, version 2.2015.

This article outlines relevant data and provides insight into panel decisions regarding various combination regimens. Additionally, a new section was added to provide additional guidance on key principles of evaluation and surgical staging in cervical cancer. This article highlights 2 areas of active investigation and debate from this new section: sentinel lymph node mapping and fertility-sparing treatment approaches. PMID: 25870376 [PubMed - in process]
Source: Journal of the National Comprehensive Cancer Network : JNCCN - Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

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AbstractObjectivesTo investigate the prognostic value of diffusion-weighted imaging (DWI) in predicting clinical outcome in patients with cervical cancer after concurrent chemoradiotherapy (CCRT).MethodsWe enrolled 124 cervical cancer patients who received definitive CCRT and underwent 3  T-MRI before and 1 month after initiating treatment. The mean apparent diffusion coefficient (ADC) value was measured on the tumor and the changes in ADC percentage (ΔADCmean) between the two time points were calculated. The Cox proportion hazard model was used to evaluate the associations between imaging or clinical varia...
Source: European Radiology - Category: Radiology Source Type: research
Authors: Gurumurthy M, Leeson S, Tidy J, Cruickshank ME Abstract Vaginal intraepithelial neoplasia (VaIN) is less common than intraepithelial neoplasia at other non-cervical sites and can be challenging to manage. This survey describes current clinical practice by colposcopists in the UK. An online questionnaire was emailed to all the lead colposcopists in U.K. A total of 86 (43%) responses were obtained. The median number of cases of VaIN seen in a year was five (range 0-100. Most clinics (95%) managed low grade VaIN conservatively. Local vaginal mucosal excision was the most common surgical procedure. Half of res...
Source: Journal of Obstetrics and Gynaecology - Category: OBGYN Tags: J Obstet Gynaecol Source Type: research
In this study, patients with early-stage cervical cancer who underwent radical and modified radical hysterectomy without retroperitoneal lymph node involvement were evaluated, and recurrence development and factors affecting disease-free survival were investigated. A nomogram consisting of factors influencing disease-free survival was constructed. The total score was determined according to the status of all risk factors. This allowed clear definition of the risk for each patient. A nomogram predicting recurrence in patients with stages IA2-IIA cervical cancer with radical hysterectomy without lymph node involvement has no...
Source: Journal of Obstetrics and Gynaecology - Category: OBGYN Tags: J Obstet Gynaecol Source Type: research
This study provides support for the use of T. camphoratus in the further development of cancer therapy.
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
A mucoadhesive nanogel is introduced to prolong the residence time and dramatically improve the drug efficiency in local cervical cancer therapy. This nanogel not only displays mucoadhesive properties that adhere strongly to mucins but also contributes to the penetration of drugs in epithelial cell monolayers. The new design with multivalent interactions exerts excellent anticancer activity in cervical cancer. AbstractCervical cancer treatment is subject to limited drug access to locally diseased targets and generally resistant to chemotherapy, thus it is essential to develop a local drug delivery system to overcome these ...
Source: Small - Category: Nanotechnology Authors: Tags: Full Paper Source Type: research
This report says that the NHS has the opportunity to upgrade cancer screening to save thousands more lives each year. It calls for people to be given much greater choice over when and where they are screened and recommends that local screening services should put on extra evening and weekend appointments for breast, cervical and other cancer checks.ReportNHS England - news
Source: Health Management Specialist Library - Category: UK Health Authors: Source Type: blogs
British Journal of Cancer, Published online: 16 October 2019; doi:10.1038/s41416-019-0593-4Performance of DNA methylation assays for detection of high-grade cervical intraepithelial neoplasia (CIN2+): a systematic review and meta-analysis
Source: British Journal of Cancer - Category: Cancer & Oncology Authors: Source Type: research
Offer more locations and evening and weekend appointments for breast, cervical and other cancer checks Related items fromOnMedica Metastatic breast cancer goes undiagnosed for too long Cancer strategies failed to improve one-year survival UK cancer survival improved, but lags behind similar nations Decision to give boys HPV jab will save thousands of lives NHS England strips Capita of cervical screening contract
Source: OnMedica Latest News - Category: UK Health Source Type: news
ConclusionBased on physical objective examination, our study yielded a Lower prevalence than that in other surveys and mainly involved anterior compartment, which suggests that it should be considered for medical intervention. Older age, postmenopausal status, and multiple vaginal deliveries increased the odds of every kind of POP.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
ConclusionNeoadjuvant chemotherapy followed by laparoscopic and open radical hysterectomy seems to be a safe treatment option for locally advanced cervical cancer, in terms of similar survival outcomes and morbidity of treatment with CCRT. However, the present study is too limited to permit conclusions due to its small sample size and retrospective design despite statistical methods for adjusting confounding factors.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
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