High-fat diet decreases H3K27ac in mice adipose-derived stromal cells

CONCLUSIONS: These results show that an HFD significantly reduces acetylation of H3K27 in ASCs and the expression of ATP-citrate lyase in subcutaneous ASCs, suggesting that, in this fat depot, the H3K27ac reduction could be partly due to lower acetyl-coenzyme A availability. H3K27ac is an epigenetic mark responsible for increasing the transcription rate and its reduction can have an important impact on ASC proliferation and differentiation potential.PMID:36062886 | DOI:10.1002/oby.23537
Source: Obesity - Category: Eating Disorders & Weight Management Authors: Source Type: research