PKC-{beta} activation inhibits IL-18-binding protein causing endothelial dysfunction and diabetic atherosclerosis

Conclusion
Our study unrevealed a new mechanism by which PKC-β activation promotes EC dysfunction caused by the de-regulation of the IL-18/IL-18BP pathway, leading to increased VCAM-1 expression, monocyte/macrophage adhesion, and accelerated atherosclerotic plaque formation in diabetes.

Source: Cardiovascular Research - April 16, 2015 Category: Cardiology Authors: Durpes, M.-C., Morin, C., Paquin-Veillet, J., Beland, R., Pare, M., Guimond, M.-O., Rekhter, M., King, G. L., Geraldes, P. Tags: Vascular biology Source Type: research