Inhibition of indoleamine 2,3-dioxygenase promotes vascular inflammation and increases atherosclerosis in Apoe-/- mice

Conclusion
IDO-mediated Trp metabolism regulates vascular inflammation and plaque formation in hypercholesterolaemic Apoe–/– mice. Our data establish that this pathway plays a major role in the pathological process of atherogenesis.

Source: Cardiovascular Research - April 16, 2015 Category: Cardiology Authors: Polyzos, K. A., Ovchinnikova, O., Berg, M., Baumgartner, R., Agardh, H., Pirault, J., Gistera, A., Assinger, A., Laguna-Fernandez, A., Back, M., Hansson, G. K., Ketelhuth, D. F. J. Tags: Vascular biology Source Type: research