Role of secreted modular calcium-binding protein 1 (SMOC1) in transforming growth factor {beta} signalling and angiogenesis
Conclusion
These results indicate that SMOC1 is an ALK5 antagonist produced by endothelial cells that tips TGF-β signalling towards ALK1 activation, thus promoting endothelial cell proliferation and angiogenesis.
Source: Cardiovascular Research - Category: Cardiology Authors: Awwad, K., Hu, J., Shi, L., Mangels, N., Abdel Malik, R., Zippel, N., Fisslthaler, B., Eble, J. A., Pfeilschifter, J., Popp, R., Fleming, I. Tags: Vascular biology Source Type: research