Role of secreted modular calcium-binding protein 1 (SMOC1) in transforming growth factor {beta} signalling and angiogenesis

Conclusion These results indicate that SMOC1 is an ALK5 antagonist produced by endothelial cells that tips TGF-β signalling towards ALK1 activation, thus promoting endothelial cell proliferation and angiogenesis.
Source: Cardiovascular Research - Category: Cardiology Authors: Tags: Vascular biology Source Type: research