Distinct mPTP activation mechanisms in ischaemia-reperfusion: contributions of Ca2+, ROS, pH, and inorganic polyphosphate

Conclusions
Transient Ca2+/polyP-mediated mPTP opening during ischaemia may serve to protect cells against cytosolic Ca2+ overload, whereas ROS/pH-mediated sustained mPTP opening on reperfusion induces cell death.

Source: Cardiovascular Research - April 16, 2015 Category: Cardiology Authors: Seidlmayer, L. K., Juettner, V. V., Kettlewell, S., Pavlov, E. V., Blatter, L. A., Dedkova, E. N. Tags: Cardiac biology and remodelling Source Type: research