Oestrogen receptor alpha in pulmonary hypertension

Conclusion
ERα is highly expressed in female hPASMCs from PAH patients and mediates oestrogen-induced proliferation of hPASMCs via mitogen-activated protein kinase and Akt signalling. Serotonin can increase ERα expression in hPASMCs and antagonism of ERα reverses serotonin-dependent PH in the mouse and increases BMPR2 expression.

Source: Cardiovascular Research - April 16, 2015 Category: Cardiology Authors: Wright, A. F., Ewart, M.-A., Mair, K., Nilsen, M., Dempsie, Y., Loughlin, L., Maclean, M. R. Tags: Integrative physiology and pathophysiology Source Type: research