Effects of cGMP/Akt/GSK-3 β signaling pathway on atrial natriuretic peptide secretion in rabbits with rapid atrial pacing

In conclusion, NPR-A interacts with ANP to regulate PGC expression, and influence the expression of cGMP during RAP, which involves in the Akt/GSK-3β signaling pathway. From the aforementioned points we conclude that cGMP regulates ANP secretion by the Akt/GSK-3β signaling pathway during atrial pacing.
Source: Frontiers in Physiology - Category: Physiology Source Type: research