The Nrf2 antioxidant defense system in intervertebral disc degeneration: Molecular insights
Experimental & Molecular Medicine, Published online: 17 August 2022; doi:10.1038/s12276-022-00829-6Insights into the activity of a protein that regulates gene expression and protects cells against oxidative stress could yield novel treatments for lower back pain. Intervertebral disc degeneration (IDD) is a common cause of lower back pain, but the molecular mechanisms underlying IDD are unclear, meaning treatment options are limited. Oxidative stress is implicated in IDD, and scientists have begun exploring the role of nuclear factor E2-related factor 2 (Nrf2), a master regulator of the body’s antioxidant responses, in regulating IDD progression. In a review of recent research, Weishi Li at Peking University Third Hospital, Beijing, China, and co-workers point out that boosting the activity of Nrf2-related signaling pathways alleviates oxidative stress in intervertebral disc cells. The researchers suggest that therapies based on non-coding RNAs may prove valuable in activating Nrf2 in IDD patients.
Source: Experimental and Molecular Medicine - Category: Molecular Biology Authors: Qian Xiang Yongzhao Zhao Jialiang Lin Shuai Jiang Weishi Li Source Type: research
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