A < em > Bcl6 < /em > Intronic Element Regulates T Follicular Helper Cell Differentiation

In this study, we demonstrated that the Bcl6 gene is regulated by FOXO1-binding, cis-acting sequences located in a highly conserved region of the first Bcl6 intron. In both mouse and human T cells, deletion of the tandem FOXO1 binding sites increased the expression of BCL6 and enhanced the proportion of TFH cells. These results reveal a fundamental control point for cellular versus humoral immunity.PMID:35948398 | DOI:10.4049/jimmunol.2100777
Source: Journal of Immunology - Category: Allergy & Immunology Authors: Source Type: research