Transcriptomic changes in the large organs in lethal meningococcal shock are reflected in a porcine shock model

ConclusionThe inflammatory responses measured on the transcriptomic level in organs in patients with fulminant meningococcal sepsis is reproduced in the porcine model of the disease, although some differences may exist regarding the top-upregulated factors in individual organs. Thus, this large animal model reproduces important immunological features of meningococcal sepsis and can be a valuable tool in further investigations of inflammatory aspects and possible treatment options
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research