Genetically engineered Salmonella promising as anti-cancer therapy

Genetically modified Salmonella can be used to kill cancer cells, scientists report. For years, researchers have known that certain strains of bacteria, including Salmonella enterica, can kill cancer cells. Specifically Salmonella enterica Serovar Typhimurium has been shown to not only colonize solid tumors, but also to exhibit an intrinsic antitumor effect. However, in order to use Salmonella as a weapon against cancer in humans, researchers must find a balance between allowing it to kill the cancer and be safe for the patient. This bacteria, commonly known for causing severe food poisoning, can lead to sepsis and death in humans.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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Nontyphoidal serovars of Salmonella enterica are pathogenic bacteria that are common causes of food poisoning. Whereas Salmonella mechanisms of host cell invasion, inflammation, and pathogenesis are mostly well established, a new possible mechanism of immune evasion is being uncovered. Programmed death ligand 1 (PD-L1) is an immunosuppressive membrane protein that binds to activated T cells via their PD-1 receptor and thereby halts their activation. PD-L1 expression plays an essential role in the immunological tolerance of self-antigens but is also exploited for immune evasion by pathogen-infected cells and cancer cells. H...
Source: Infection and Immunity - Category: Infectious Diseases Authors: Tags: Host Response and Inflammation Source Type: research
When the Affordable Care Act (ACA) was passed a little over six years ago, it brought with it the promise of health insurance for all Americans. It also sought to begin to shift the paradigm for health care in this country, emphasizing value over volume, and recognizing the importance of prevention coupled with appropriate access to care. By now, it is well known that repealing the ACA could leave nearly 20 million Americans uninsured and simultaneously result in millions of job losses across the country. An associated cost that has been less discussed, but no less relevant, is what repeal could mean for the nation’s...
Source: Health Affairs Blog - Category: Health Management Authors: Tags: Costs and Spending Following the ACA Public Health Big Cities Health Coalition Community Health Prevention and Public Health Fund. Source Type: blogs
Credit: WHO/Jim HolmesBy IPS World DeskROME/GENEVA, Feb 28 2017 (IPS)The United Nations health organisation has just published its first ever list of antibiotic-resistant “priority pathogens” – a catalogue of 12 families of bacteria that pose the greatest threat to human health. The list was drawn up in a bid to guide and promote research and development (R&D) of new antibiotics, as part of the World Health Organization (WHO) efforts to address growing global resistance to antimicrobial medicines.The list highlights in particular the threat of gram-negative bacteria that are resistant to multiple antibiot...
Source: IPS Inter Press Service - Health - Category: Global & Universal Authors: Tags: Featured Global Headlines Health Human Rights TerraViva United Nations Source Type: news
A COMMON food poisoning bug can act as a "Trojan horse" to help the immune system fight cancer, scientists have discovered.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Use of these medicines shown to increase risk of C. difficile and Campylobacter infections Related items fromOnMedica C diff used to fight C diff Long-term aspirin use linked to lower risk of gastrointestinal tract cancers One in three at risk of campylobacter food poisoning during their lifetime Norovirus a huge cause of gastroenteritis worldwide Salmonella linked to imported eggs
Source: OnMedica Latest News - Category: UK Health Source Type: news
CANCER could be stopped in its tracks by a strain of salmonella - a bacteria which can cause food poisoning. Experts said the bacteria could shrink cancerous tumours without targeting healthy cells.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Conclusion This laboratory study principally demonstrates that salad leaf juice – released from salad leaves when they are damaged or broken – supports the growth of salmonella bacteria, even at fridge temperature. If leaves are contaminated with salmonella, this isn't removed by washing in water. The results don't show that all packaged salad leaves are contaminated with gut bacteria like salmonella. What they do show is that if the bags have been contaminated with gut bacteria, these bacteria will replicate, even in the fridge, and there's little you can do to remove them. The best thing to do is to throw t...
Source: NHS News Feed - Category: Consumer Health News Tags: Food/diet Source Type: news
Add Pennsylvania to the list of Chipotle poisoning outbreak states. Co-author: Andrew Porterfield The number of recent food poisoning cases linked to the fast-food restaurant soared this week to more than 500 with the Centers for Disease Control and Prevention announcing 6 additional cases in four more states: Pennsylvania, North Dakota, Kansas and Oklahoma. "For more than 15 years, we've been working hard to change the way people think about and eat fast food," Chipotle Co-CEO and founder Steve Ells told Fortune earlier this year. Well, Ells nailed that one. Most of the Salmonella, norovirus and E. coli outbre...
Source: Science - The Huffington Post - Category: Science Source Type: news
This article originally appeared on Health.com. More from Health.com: 25 Fresh Corn Recipes for Summer 17 Easy Ways to Burn Calories This Summer 12 Reasons Dehydration Is Bad for Your Body -- This feed and its contents are the property of The Huffington Post, and use is subject to our terms. It may be used for personal consumption, but may not be distributed on a website.
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
scientists think the nasty microbe could be turned to good purpose: to fight cancers. Sounds odd, but there's a rhyme and reason to such thinking, as described in a pretty interesting news article published in the journal Nature Medicine. (It's one of a number of news articles on cancer topics in the journal this month.)
Source: AARP.org News - Category: American Health Source Type: news
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