Oligomerization of the HBV/HDV functional receptor NTCP expressed in Sf9 insect cell

CONCLUSION: Dimer is the predominant form of NTCP expressed in Sf9 when solubilized with detergent. FRET and Co-IP analysis support that NTCP forms oligomers in Sf9 cell.GENERAL SIGNIFICANCE: Our results showed that NTCP formed oligomers in Sf9 cell. Meanwhile the FRET analysis of NTCP variants further elucidated the molecular mechanism of NTCP oligomerization.PMID:35944837 | DOI:10.1016/j.bbagen.2022.130224
Source: Biochimica et Biophysica Acta - Category: Biochemistry Authors: Source Type: research