Aldose reductase promotes diet-induced obesity via induction of senescence in subcutaneous adipose tissue

CONCLUSIONS: AKR1B1/Akr1b3 modulation of senescence in subcutaneous adipose tissue contributes to aberrant metabolic responses to high-fat feeding. These data unveil new opportunities to target these pathways to combat obesity.PMID:35894077 | DOI:10.1002/oby.23496

Source: Obesity - July 27, 2022 Category: Eating Disorders & Weight Management Authors: Devi Thiagarajan Nosirudeen Quadri Shabnam Jawahar Hylde Zirpoli Carmen Hurtado Del Pozo Raquel L ópez-Díez Syed Nurul Hasan Gautham Yepuri Paul F Gugger Brian S Finlin Philip A Kern Kenneth Gabbay Ann Marie Schmidt Ravichandran Ramasamy Source Type: research