Osteoarthritis and chronic pain: Interleukin-6 as a common denominator and therapeutic target

Sci Signal. 2022 Jul 26;15(744):eadd3702. doi: 10.1126/scisignal.add3702. Epub 2022 Jul 26.ABSTRACTOsteoarthritis (OA) is a common and problematic disorder that is often associated with chronic pain, a combination that renders OA a leading cause of physical disability and an unmet clinical challenge. In this issue of Science Signaling, Liao et al. show that interleukin-6 is a driver of both joint tissue degradation and pain, revealing a common culprit and a possible comprehensive target of therapeutic intervention.PMID:35881690 | DOI:10.1126/scisignal.add3702
Source: Science Signaling - Category: Biomedical Science Authors: Source Type: research