Her2/EGFR-PDGFR pathway aberrations associated with tamoxifen response in metastatic breast cancer patients

CONCLUSIONS: Genetic profiling using simple quantitative real-time polymerase chain reaction (qRT-PCR) protocols could be used to assess response to tamoxifen treatment in MBC patients. According to our data, a five-gene panel in the EGFR pathway (JAK1, COL1A1, GAB1, FN1 and MKNK1) could be used to categorize MBC patients into groups according to treatment response.PMID:35871690 | DOI:10.1186/s43046-022-00132-5
Source: J Egypt Natl Canc In... - Category: Cancer & Oncology Authors: Source Type: research