When underlying biology threatens the randomization principle — initial gout flares of urate-lowering therapy

Nature Reviews Rheumatology, Published online: 25 July 2022; doi:10.1038/s41584-022-00804-5The paradoxical increase in gout flare risk upon initiation of urate-lowering therapy presents challenges for the measurement and analysis of gout flares in clinical trials of urate-lowering therapy. In this Perspective, the authors highlight these issues and discuss potential solutions.
Source: Nature Reviews Rheumatology - Category: Rheumatology Authors: Source Type: research