Computer Applications Making Rapid Advances in High Throughput Microbial Proteomics (HTMP).

Computer Applications Making Rapid Advances in High Throughput Microbial Proteomics (HTMP). Comb Chem High Throughput Screen. 2014 Jan 16; Authors: Anandkumar B, Haga SW, Wu HF Abstract The last few decades have seen the rise of widely-available proteomics tools. From new data acquisition devices, such as MALDI-MS and 2DE to new database searching softwares, these new products have paved the way for high throughput microbial proteomics (HTMP). These tools are enabling researchers to gain new insights into microbial metabolism, and are opening up new fields of study, such as protein-protein interactions (interactomics) and drug discovery. Computer software is a key part of these emerging fields. This current review considers: 1) software tools for identifying the proteome, such as MASCOT or PDQuest, 2) online databases of proteomes, such as SWISS-PROT, Proteome Web, or the Proteomics Facility of the Pathogen Functional Genomics Resource Center, and 3) software tools for applying proteomic data, such as PSI-BLAST or VESPA. These tools allow for the study of such diverse fields as network biology, protein identification, functional annotation, target identification/validation, protein expression, protein structural analysis, metabolic pathway engineering and drug discovery. PMID: 24433413 [PubMed - as supplied by publisher]
Source: Combinatorial Chemistry and High Throughput Screening - Category: Chemistry Authors: Tags: Comb Chem High Throughput Screen Source Type: research