Neurodevelopmental Implications of the General Anesthesia in Neonate and Infants.
Neurodevelopmental Implications of the General Anesthesia in Neonate and Infants. Exp Neurol. 2015 Apr 7; Authors: Lee JH, Zhang J, Wei L, Yu SP Abstract Each year, about six million children, including 1.5 million infants, in the United States undergo surgery with general anesthesia, often requiring repeated exposures. However, a crucial question remains of whether neonatal anesthetics are safe for the developing central nervous system (CNS). General anesthesia encompasses the administration of agents that induce analgesic, sedative, and muscle relaxant effects. Although the mechanisms of action of general anesthetics are still not completely understood, recent data have suggested that anesthetics primarily modulate two major neurotransmitter receptor groups, either by inhibiting N-methyl-D-aspartic acid (NMDA) receptors, or conversely by activating γ-aminobutyric acid (GABA) receptors. Both of these mechanisms result in the same effect of inhibiting excitatory activity of neurons. In developing brains, which are more sensitive to disruptions in activity-dependent plasticity, this transient inhibition may have longterm neurodevelopmental consequences. Accumulating reports from preclinical studies show that anesthetics in neonates cause cellular toxicity including apoptosis and neurodegeneration in the developing brain. Importantly, animal and clinical studies indicate that exposure to general anesthetics may affect CNS development, resulting in lo...
In conclusion, the new mild WI protocol is a superior experimental model to study the pathophysiological effects of elevated ICP induced by water intoxication. PMID: 31534063 [PubMed - as supplied by publisher]
Ive searched for advice on personal statements and I found a personal statement readers for pre-medical. Is there a list of people willing to read personal statements for ERAS or is there anyone here that would be willing to read my personal statement? I know its a little late to ask about this, but I had some personal issues come up that delayed my ability to finish the statement.
Who is doing these ipack blocks? Could you describe your transducer position, and where it’s most important to inject? How successful are they? Trying to start doing these blocks.
Short version. Sick elderly lady for upper and lower GI before her TAVR for GI bleeding. Severe AS with SOB, Marlena with Hb that has now stabilized, no nausea, did a bowel prep last night, reassuring airway. GETA? Anyone would try MAC?
After looking at this board I think it would be good to start a list of programs that terminate residents. I have a format in mind. Please give calendar year of termination, institution, specialty, PGY level of terminated resident, and reason if known Example: 2009 - University of XXXX - Anesthesiology - PGY-2 - poor performance on inservice exam I think this could be a valuable resource for future residents.
Conclusion: Emergency SBE under general anesthesia achieves higher diagnosis and detection rates, and fewer adverse events under conscious sedation, when compared to nonemergency SBE, regardless of the route. For patients with overt bleeding, it is easier to find lesions by emergency SBE within 24 hours. PMID: 31534450 [PubMed]
Hi all, I did a quick search and wasn't able to find this previously posted, so I apologize if this is a repeated question. regarding topicalization and premedication for an awake fiberoptic intubation, I know there are dozens of ways to skin this cat. I'm at the point in my training where I've tried a few different methods with varying degrees of success, yet have not settled on any "best way" to do it. I'm just curious to see how those of you go about it, and if you have any tips/tricks... awake fiberoptic topicalization/premedication
I have been fortunate enough to be accepted to both these great schools. I enjoyed both interviews, but enjoyed my AZCOM one more. I think they are both great schools with good match lists and good board scores. I am interested in keeping my options open to some of those more competitive specialties and do not want to feel like the school I attend will not prepare me for boards in a way where I can be competitive for things like surgery, anesthesiology, emergency med etc, if that is the path... RVUCOM-CO vs AZCOM
Senstend, a spray containing lidocaine/prilocaine, can improve ejaculatory control and sexual satisfaction and reduce distress related to ejaculation, the EMA said.International Approvals
Publication date: Available online 20 September 2019Source: Best Practice &Research Clinical AnaesthesiologyAuthor(s): Jeremy Green, Kelly S. Davidson, Sonja Gennuso, Morgan Brown, Allison Pinner, Jordan Renschler, Kelsey Cramer, Rachel J. Kaye, Elyse M. Cornett, Alan D. Kaye, Ira W. Padnos, Richard D. Urman, Charles J. FoxAbstractPurposeof review: The purpose of this manuscript is to provide a brief discussion of the current direction in pediatric regional anesthesia, highlighting both newer nerve blocks and techniques, as well as traditional blocks.Recent findingsThe number of nerve blocks performed in pediatric pati...