Evidence supporting safe diagnosis of coeliac disease in children with antitissue transglutaminase titre >=5 times upper limit of normal

Conclusion
99.5% of children with TGA-IgA ≥5xULN had histological confirmation of CD, suggesting that CD diagnosis can be made securely in children with TGA-IgA ≥5xULN. If other studies confirm this finding, there is a case to be made to modify the ESPGHAN guidelines to a lower threshold of TGA-IgA for serological diagnosis of CD.

Source: Archives of Disease in Childhood - July 19, 2022 Category: Pediatrics Authors: Paul, S. P., Raja, D. I., Sandhu, B. K., Rao, S. R., Spray, C. H., Wiskin, A. E., Selvarajan, L., Volonaki, E., Ramani, P., Tashtoush, L. B., Basude, D. Tags: Original research Source Type: research