Serum neurofilament as a predictor of 10-year grey matter atrophy and clinical disability in multiple sclerosis: a longitudinal study
Conclusion
Higher sNfL levels during periods of active inflammation predicted more GM atrophy and specific aspects of clinical disability 10 years later. The findings suggest that subsequent long-term GM atrophy is mainly due to neuroaxonal degradation within new lesions.
Source: Journal of Neurology, Neurosurgery and Psychiatry - Category: Neurosurgery Authors: Lie, I. A., Kacar, S., Wesnes, K., Brouwer, I., Kvistad, S. S., Wergeland, S., Holmoy, T., Midgard, R., Bru, A., Edland, A., Eikeland, R., Gosal, S., Harbo, H. F., Kleveland, G., Sorenes, Y. S., Oksendal, N., Varhaug, K. N., Vedeler, C. A., Barkhof, F., T Tags: Open access Multiple sclerosis Source Type: research