Effects of Combined Exposure to Lead and High-Fat Diet on Bone Quality in Juvenile Male Mice

Conclusions: Pb and HFD produce selective deficits in bone accrual that are associated with alterations in progenitor cell activity that may involve reduced Wnt signaling. This study emphasizes the need to assess toxicants together with other risk factors relevant to human health and disease.

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Citation: Beier EE, Inzana JA, Sheu TJ, Shu L, Puzas JE, Mooney RA. Effects of Combined Exposure to Lead and High-Fat Diet on Bone Quality in Juvenile Male Mice. Environ Health Perspect; http://dx.doi.org/10.1289/ehp.1408581.
Received: 21 April 2014
Accepted: 8 April 2015
Advance Publication: 10 April 2015
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Source: EHP Research - April 10, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Research Article Source Type: research