CD8-positive Lymphocytes in Graft-Versus-Host Disease of Humanized NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ Mice

This study expands on recently reported microscopical features of GvHD in NSG-hu-BLT mice and suggests a role for CD8+ T lymphocytes in the progression of the disease. NSG-hu-BLT mice represent an excellent model of GvHD, but its prevalence may compromise their use in other fields of biomedical research.
Source: Journal of Comparative Pathology - Category: Pathology Source Type: research