Angiotensin AT2 receptor agonist prevents salt-sensitive hypertension in obese Zucker rats.

Angiotensin AT2 receptor agonist prevents salt-sensitive hypertension in obese Zucker rats. Am J Physiol Renal Physiol. 2015 Apr 8;:ajprenal.00002.2015 Authors: Ali Q, Patel SN, Hussain T Abstract High sodium intake is a risk factor for the pathogenesis of hypertension, especially in obesity. The present study is designed to investigate whether angiotensin type-2 receptor activation with selective agonist C21 prevents high-sodium diet (HSD)-induced hypertension in obese animals. Male obese rats were treated with AT2R agonist C21 (1 mg/kg/day, oral) while maintained on either normal-sodium diet (NSD, 0.4%) or HSD (4%) for 2-weeks. Radio-telemetric recording showed a time dependent increase in systolic blood pressure in HSD-fed obese rats, being maximal increase (~27 mmHg) at day 12 of the HSD regimen. C21 treatment completely prevented the increase in blood pressure of HSD-fed rats. Compared to NSD controls, HSD-fed obese rats had greater natriuresis/diuresis and urinary levels of nitrates, and these parameters were further increased by C21 treatment. HSD-fed rats expressed higher level of cortical AngII, which was reduced to 50% by C21 treatment. HSD feeding and/or C21 treatment had no effects on cortical renin activity and the expression of angiotensin converting enzyme and chymase, which are AngII producing enzymes. However, Ang(1-7) concentration and ACE2 activity in the renal cortex were reduced by HSD feeding, and C21 treatment ...
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research