Vancomycin MIC creep in methicillin-resistant Staphylococcus aureus (MRSA) isolates from 2006 to 2010 in a hospital in China
W Chang, Xiaoling Ma, P Gao, X Lv, H Lu, F ChenIndian Journal of Medical Microbiology 2015 33(2):262-266Purpose: To assess whether vancomycin minimum inhibitory concentration (MIC) creeps among clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) in a regional hospital in China. Furthermore, to analyze the causes of vancomycin MIC creeps and the relationship between vancomycin MICs and the outcome among patients with MRSA infection. Materials and Methods: All clinical isolates of MRSA from 2006-2010 were retrieved and tested by the broth microdilution procedure to determine their vancomycin MIC. Meanwhile, related patient records were analyzed. Results: While all isolates were susceptive to vancomycin, the percentage of isolates with a vancomycin MIC = 1 mg/L increased significantly from 2006 (37.0%) to 2010 (75.7%). Meanwhile, vancomycin usage density (DDDs/1000 bed-days) had increased significantly from 2006-2010. Mean linear correlation analysis showed a statistically significant positive correlation (r = 0.905, P
The objective of this study was to systematically evaluate the in vitro activity of cefoselis and other comparators against common bacterial pathogens collected from 18 hospitals across China. Minimum inhibitory concentrations (MICs) were determined by the broth microdilution method following Clinical and Laboratory Standards Institute (CLSI) guidelines. Cefoselis showed poor activity against extended-spectrum β-lactamase (ESBL)-producing Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis, with susceptibility rates of
In conclusion, our work may pave the way for the development of indole derivatives as adjuvants to potentiate aminoglycosides against gram-positive pathogens.
Publication date: Available online 24 February 2020Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Juan Li, Ashna Gopal, Sena Karaosmanoglu, Jiafu Lin, Tasnim Munshi, Wenjun Zhang, Xianfeng Chen, Li Yan
CONCLUSION: The knowledge of hand hygiene practices, high frequency of handwashing, and wearing different gloves during the procedure of each patient decrease S.aureus nasal carriage in HCWs. In addition mupirocin is still effective in nasal S.aureus carriers. PMID: 32096773 [PubMed - in process]
(Marshall University Joan C. Edwards School of Medicine) Three Marshall University scientists received a three-year grant from the National Institutes of Health (NIH) to study the use of disulfiram in the treatment of antibiotic-resistant Staphylococcus aureus infections.
ConclusionsThe results indicated a high prevalence ofS. arueus and MRSA nasal colonization among pediatric ICU patients in Taiwan. Identification of epidemic clones warrants the implement of infection control measures to reduce colonization and prevent the dissemination of MRSA in hospitals.
(American Chemical Society) Public health agencies worldwide have identified antibiotic resistance of disease-causing bacteria as one of humanity's most critical challenges. However, scientists haven't discovered a new class of antibiotics in more than 30 years. Now, researchers reporting in ACS Infectious Diseases have uncovered the hidden antibiotic potential of a non-psychoactive cannabis compound called cannabigerol (CBG), which helped control methicillin-resistant Staphylococcus aureus (MRSA) infections in mice.
Conclusions. In the era of increasing use of molecular-based microbiology assays, the thermonuclease test remains a simple, inexpensive and robust test for the presumptive identification of S. aureus cultured from blood, irrespective of methicillin sensitivity. PMID: 32101159 [PubMed - as supplied by publisher]
IJERPH, Vol. 17, Pages 1500: Assessing the Potential Impact of a Long‐Acting Skin Disinfectant in the Prevention of Methicillin‐ Resistant Staphylococcus aureus Transmission International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17051500 Authors: Short Mietchen Lofgren Healthcare‐associated transmission of methicillin‐resistant Staphylococcus aureus (MRSA)remains a persistent problem. The use of chlorhexidine gluconate (CHG) as a means of decolonizingpatients, either through targeted decolonization or daily bathing, is frequently used to supplementother interventions. ...
ConclusionThere was a significant association of antibiotic therapy and age on S. aureus carriage profiles in CF patients indicating that antibiotic therapy prevents acquisition of new clones, while during aging of patients with persisting S. aureus, dominant clones were selected and mutations in the spa-repeat region accumulated.