B-cell lymphoma-associated hemophagocytic lymphohistiocytosis: A case report

Oncol Lett. 2022 Jun 7;24(2):246. doi: 10.3892/ol.2022.13365. eCollection 2022 Aug.ABSTRACTHemophagocytic lymphohistiocytosis (HLH) is a life-threatening condition characterized by an exaggerated but dysregulated immune response resulting in hyperinflammation, with a potential for progression to multiple organ dysfunction and failure. Infectious diseases, inflammatory disorders, malignancies and immunodeficiency syndromes are known triggers of HLH in adults. The present study reported the case of a middle-aged man with HLH triggered by B-cell lymphoma who was successfully treated with dexamethasone; etoposide, prednisone, vincristine, cyclophosphamide, hydroxy-doxorubicin and rituximab chemotherapy; and multiple intrathecal methotrexate with a good outcome.PMID:35761945 | PMC:PMC9214690 | DOI:10.3892/ol.2022.13365

Source: Oncology Letters - June 28, 2022 Category: Cancer & Oncology Authors: Ademola S Ojo Joseph Asemota Somtochukwu Ojukwu Ahmad Rajeh Amina Bot Caitlyn J Smith Katsiaryna Laziuk Mohammed Saleh Source Type: research