Differentiation and Maturation Effect of All-trans Retinoic Acid on Cultured Fetal RPE and Stem Cell-Derived RPE Cells for Cell-Based Therapy

CONCLUSIONS: Differences in protein and gene expression among three RPE types exist. ATRA can increase RPE markers, CRPs gene expression in fRPE and stem cell-derived RPE. These can be used to guide the standard of screening RPE cells for clinical translational cell therapy.PMID:35763026 | DOI:10.1080/02713683.2022.2079144

Source: Cell Research - June 28, 2022 Category: Cytology Authors: Tingyu Yan Na Yang Wei Hu Xinxin Zhang Xuedong Li Youjin Wang Jun Kong Source Type: research