Steroid responsive encephalopathy associated with autoimmune thyroiditis (SREAT) with stroke like symptoms. A case report. (P5.104)
Objective: To report an unusual case of Steroid responsive encephalopathy associated with autoimmune thyroiditis (SREAT) with stroke like symptoms. Background: SREAT is a rare disorder commonly seen in females. Two clinic subtypes have been described, encephalopathic and vasculitic types. The hallmark-presenting feature is a nonspecific encephalopathy. Additional manifestations include, seizures, aphasia, extrapyramidal signs, myoclonus, gait disorder, neuropsychiatric symptoms and stroke-like episodes. Corticosteroids are the main stay of therapy. Design and methods: Case report and pertinent literature review. Results: 32 year old female without any significant past medical history presented with numbness of right face, right upper extremity along with right hand grip weakness. Neurological examination only revealed right pronator drift and right upper extremity sensory hypoesthesia to light touch and pin prick. MRI showed white mater hyper-intensities in the cortical and sub cortical region with minimal enhancement. CSF glucose, protein, cell count within normal range. CSF oligiclonal bands, IgG index and meningoencephalitis panel was negative. Autoimmune work including NMDAR, VGKC and paraneoplastic panel was negative. CT angiogram of the head and neck was not suggestive of vasculitis. Work up revealed significantly elevated thyroid peroxidase antibodies (602 IU/ml, normal
CONCLUSION: The cost-effectiveness analysis suggests that double low-dose budesonide is a dominant Step 3 treatment strategy compared with low-dose budesonide plus montelukast for patients aged 1 to 5 years with persistent asthma in China. PMID: 32991222 [PubMed - as supplied by publisher]
CONCLUSION: RTX could be an effective and relatively safe therapeutic option in patients with refractory IIM. PMID: 32989931 [PubMed - in process]
Authors: McNamara A, Roebke K, Danthi P Abstract Infection of host cells by mammalian reovirus in culture or in tissues of infected animals results in cell death. Cell death of infected neurons and myocytes contributes to the pathogenesis of reovirus-induced encephalitis and myocarditis in a newborn mouse model. Thus, reovirus-induced cell death has been used to investigate the basis of viral disease. Depending on the cell type, infection of host cells by reovirus results in one of two forms of cell death-apoptosis and necroptosis. In addition to the obvious differences in how these two forms of cell death are exec...
Authors: Yu JF, Pung L, Minami H, Mueller K, Khangura R, Darflinger R, Hetts SW, Cooke DL Abstract BACKGROUND: Digital subtraction angiography (DSA) remains the gold standard for angiographic evaluation of cerebrovascular pathology, however, multiple acquisitions requiring additional time and radiation are often needed. In contrast, 3D-DSA provides volumetric information from a single injection but neglects temporal information. Four-dimensional-DSA (4D-DSA) combines temporal information of 2D-DSA with volumetric information of 3D-DSA to provide time-resolved tomographic 3D reconstructions, potentially reducing pro...
Conclusions: More effort is needed to identify what fetal and maternal factors are associated with low birth weight and IBS. A well-executed prospective birth cohort with a collection of bio-samples and functional data will provide a better understanding of how adversity and the interplay between genetics, epigenetics, and numerous risk factors affect the development of IBS. PMID: 32989183 [PubMed]
CONCLUSION: IRVAN syndrome is a rare condition that may progress rapidly and cause severe vision loss without treatment. The photocoagulation is beneficial and should be performed in the early phase. The aneurysms presented extensive dynamic changes through multimodal imaging which suggested a migratory inflammatory process involving retinal arterioles. PMID: 32990491 [PubMed - as supplied by publisher]
CONCLUSION: Branched retinal artery occlusion with intraretinal and vitreous hemorrhage, panuveitis, and multiple iris holes may suggest the presence of an intraocular parasite. PMID: 32990490 [PubMed - as supplied by publisher]
Authors: Abu El-Asrar AM, Dheyab A, Khatib D, Struyf S, Van Damme J, Opdenakker G Abstract PURPOSE: To evaluate the efficacy of B cell depletion therapy with the chimeric mouse/human anti-CD20 monoclonal antibody rituximab for refractory chronic recurrent granulomatous uveitis associated with Vogt-Koyanagi-Harada (VKH) disease. METHODS: Retrospective study of 9 patients (18 eyes) who failed to respond to conventional combination immunosuppressive therapy. RESULTS: All the patients received 3 rituximab infusions. The follow-up period after initiation of rituximab therapy ranged from 9 to 36 months (mean...
Conditions: Cushing's Disease; Pituitary Adenoma Intervention: Drug: Acthrel Sponsor: National Institute of Neurological Disorders and Stroke (NINDS) Recruiting
Conditions: Stroke; Mastication Disorder; Temporomandibular Disorders; Dysphagia; Stomatognathic Diseases Intervention: Other: Expiratory muscle training Sponsor: Abant Izzet Baysal University Recruiting