Updated HHS Adult and Adolescent Antiretroviral Treatment Guidelines Released

The HHS Panel on Antiretroviral Guidelines for Adults and Adolescents announces the release of the updated Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents. Key updates to the guidelines include additions and changes to the following guideline sections: What to Start: Significant changes to the list of Recommended, Alternative, and Other regimens for treatment-naive patients prompted by recent findings from clinical trials and cohort studies, as well as experience in clinical practice. Addition of a new table to assist clinicians in selecting an initial ARV regimen based on specific clinical scenarios and ARV-related considerations. Management of the Treatment-Experienced Patient: Expanded information on the management of patients failing first and second ART regimens, and new information about isolated CNS virologic failure and new onset neurologic symptoms. A new section to highlight information on poor CD4 cell recovery and persistent inflammation and the increased risk of morbidity. Drug Interactions: A new table outlining the mechanisms of interaction of ARV drugs. Updates to all drug-drug interaction tables, particularly to those related to ritonavir- or cobicistat-boosted ARV drugs. In addition, the Acute/Early HIV Infection, HIV-2 Infection, and HIV/Hepatitis C Virus (HCV) Coinfection sections have been updated to reflect the most recent information relevant to each section. For a complete preview...

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(Johns Hopkins Medicine) Johns Hopkins scientists report they have identified two potential new drug targets for the treatment of HIV. The finding is from results of a small, preliminary study of 19 people infected with both HIV -- the virus that causes AIDS -- and the hepatitis C virus. The study revealed that two genes -- CMPK2 and BCLG, are selectively activated in the presence of type 1 interferon, a drug once used as the first line of treatment against hepatitis C.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
(Drugs for Neglected Diseases Initiative) FIND and the DNDi   will partner to generate evidence that will support policy change and scale up of hepatitis C diagnosis and treatment. This work, announced at the AIDS 2018 conference in Amsterdam and ahead of World Hepatitis Day 2018, is being conducted in collaboration with the Ministry of Health in Malaysia with a view to overcoming barriers to diagnosis and treatment.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Sadly, stigma around health conditions remains a part of many patients ’ lives. Many will not disclose a diagnosis for fear of being judged by peers, employers, health professionals, colleagues and wider society. In fact, there is clear evidence that such negative societal attitudes impact health outcomes, resulting in diagnosis delays and impaired treatment.Some diseases are heavily stigmatized – including mental health, HIV/AIDS, hepatitis and some skin conditions – leading people to restrict their participation in society, impairing their chances of living happy, healthy lives.However, to one extent or...
Source: EyeForPharma - Category: Pharmaceuticals Authors: Source Type: news
CONCLUSION: HIV/HCV co-infection was found to be more prevalent than HIV/HBV co-infection in a Serbian cohort. Co-infection with HCV was related to more profound immunodeficiency prior to therapy initiation, reflecting a possible unfavorable impact of HCV on the natural history of HIV infection. PMID: 30014804 [PubMed - as supplied by publisher]
Source: Current HIV Research - Category: Infectious Diseases Authors: Tags: Curr HIV Res Source Type: research
Objective: To assess the possible association between the use of direct antiviral agents (DAA) and the risk of hepatocellular carcinoma (HCC) in HIV/hepatitis C virus (HCV)-coinfected patients. Methods: The GEHEP-002 cohort recruits HCC cases in HIV-infected patients from 32 centers from Spain. Three analyses were performed: the proportion of HCC cases after sustained virological response (SVR) and the evolution of this proportion over time, the frequency of HCC after SVR in HIV/HCV-coinfected patients with cirrhosis, and the probability of HCC recurrence after curative therapies among those undergoing HCV therapy. R...
Source: AIDS - Category: Infectious Diseases Tags: Clinical Science Source Type: research
United States healthcare policy is currently in the spotlight as the Trump administration seeks to weaken Obamacare with actions such as the Tax Cuts and Jobs Act, which removes the individual mandate that required individuals to carry health insuran...
Source: Medgadget - Category: Medical Devices Authors: Tags: Exclusive Medicine Net News Public Health Society Source Type: blogs
hologie e.V. (DGP), Deutsche Leberstiftung, Gesellschaft für Virologie e.V. (GfV), Gesellschaft für Pädiatrische Gastroenterologie und Ernährung (GPGE), Österreichische Gesellschaft für Gastroenterologie und Hepatologie (ÖGGH), Schweizerische Gesellschaft für Gastroenterologie (SGG), Deutsche Transplantationsgesellschaft e.V. (DTG), Deutsche Leberhilfe e.V., Deutsche Gesellschaft für Infektiologie e.V. (DGI), Deutsche Gesellschaft für Suchtmedizin e.V. (DGS), Deutsche AIDS-Gesellschaft e.V. (DAIG), Deutsche Arbeitsgemeinschaft niedergelassener Ärzte für die Versor...
Source: Zeitschrift fur Gastroenterologie - Category: Gastroenterology Authors: Tags: Z Gastroenterol Source Type: research
AbstractPurpose of ReviewThe purpose of this review is to address infection with HIV and hepatitis C in the Appalachian region of the USA and the driving forces underlying this epidemic. We seek to discuss epidemiology of disease and the possible interventions to reduce incidence and burden of disease in this resource-limited area.Recent FindingsThe rise of the opioid crisis has fueled a rise in new hepatitis C infection, and a rise in new HIV infection is expected to follow. Injection drug use has directly contributed to the epidemic and continues to remain a risk factor. Men who have sex with men remains a significant ri...
Source: Current HIV/AIDS Reports - Category: Infectious Diseases Source Type: research
AIDS Research and Human Retroviruses, Ahead of Print.
Source: AIDS Research and Human Retroviruses - Category: Infectious Diseases Authors: Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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