Updated HHS Adult and Adolescent Antiretroviral Treatment Guidelines Released

The HHS Panel on Antiretroviral Guidelines for Adults and Adolescents announces the release of the updated Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents. Key updates to the guidelines include additions and changes to the following guideline sections: What to Start: Significant changes to the list of Recommended, Alternative, and Other regimens for treatment-naive patients prompted by recent findings from clinical trials and cohort studies, as well as experience in clinical practice. Addition of a new table to assist clinicians in selecting an initial ARV regimen based on specific clinical scenarios and ARV-related considerations. Management of the Treatment-Experienced Patient: Expanded information on the management of patients failing first and second ART regimens, and new information about isolated CNS virologic failure and new onset neurologic symptoms. A new section to highlight information on poor CD4 cell recovery and persistent inflammation and the increased risk of morbidity. Drug Interactions: A new table outlining the mechanisms of interaction of ARV drugs. Updates to all drug-drug interaction tables, particularly to those related to ritonavir- or cobicistat-boosted ARV drugs. In addition, the Acute/Early HIV Infection, HIV-2 Infection, and HIV/Hepatitis C Virus (HCV) Coinfection sections have been updated to reflect the most recent information relevant to each section. For ...